The rapid evolution of bioelectronics has opened new directions in tissue engineering, driving major advancements in the biomedical sector. This talk will present the transformative potential of organic bioelectronics, highlighting their role in interfacing seamlessly with biological tissues to enable real-time monitoring, diagnostics, and therapeutic interventions. Our recent developments for in vitro bioelectronics will be demonstrated, emphasizing the integration of biomimetic materials and innovative design approaches that ensure functionality and longevity within the biological environment. Additionally, this talk will extend to energy harvesting devices, namely triboelectric nanogenerators (TENGs). TENGs have emerged as revolutionary sustainable devices, particularly in the fields of bioelectronics and wearable electronics. By harnessing the triboelectric effect, TENGs convert mechanical energy from body movements or environmental sources into electrical energy, offering green energy alternatives and sensing capabilities. Our research introduces new design approaches to enhance the performance and flexibility of TENGs by incorporating bio-derived materials and nanocoatings through chemical synthesis and surface engineering. Our findings demonstrate that these devices can operate efficiently under various conditions, making them highly adaptable for diverse applications. By advancing the design and functionality of TENGs, our research contributes to developing next-generation, eco-friendly energy solutions, addressing the critical need for sustainable technology in our society.